Philadelphia chromosome

基本解釋

The Philadelphia chromosome (universally present in CML) is lacking in patients with leukemoid reactions.
費(fèi)城染色體（一般出現(xiàn)在CML）在白血病樣反應(yīng)中一般不出現(xiàn)。
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Philadelphia chromosome formed may result in the generation of the fusion protein BCR ABL, a constitutively activated tyrosine ki nas e which then causes chronic myeloid leukemia (CML).
慢性粒細(xì)胞白血?。–ML）患者體內(nèi)有異常染色體形成并產(chǎn)生BCR ABL融合蛋白，該融合蛋白能激活酪氨酸激酶，刺激細(xì)胞過度增生導(dǎo)致慢性粒細(xì)胞白血病的發(fā)生。

The drug was originally developed as Imatinib using rational drug design after Philadelphia chromosome mutation was discovered.
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費(fèi)城染色體
It is observed that besides the Philadelphia chromosome, more than 80% patients have genetical and chromosomal abnormalities such as the triploidy of 8, 19 chromosomes, while at the molecular level, p53 gene mutation occurs, whose mechanism is still unclear nowadays.
急變期出現(xiàn)除費(fèi)城染色體以外的遺傳學(xué)和染色體的改變,如染色體8和19的三倍體,而在分子水平出現(xiàn)p53基因的突變,其機(jī)理目前尚不清楚。
生物學(xué)
費(fèi)城染色體