allosteric activator

基本解釋

Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.
細胞周期蛋白D1作為一個能促進有絲分裂和CDK4的變構(gòu)激活劑，是癌癥中較頻繁變化的細胞周期調(diào)節(jié)子。
Phosphorylation leads to inactivation of GS, but activity is restored by the binding of the allosteric activator glucose-6-phosphate, which induces its dephosphorylation and activation (4).
磷酸化會抑制GS活性，但活性可被變異配體6-磷酸葡萄糖結(jié)合后恢復(fù)，6-磷酸葡萄糖可以誘導(dǎo)GS的去磷酸化從而激活。
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