Bonta

基本解釋

Competing ELISA showed that recombinant ScFv could compete with antiserum to specific hind BoNTa.
競爭活性測定結果表明，重組抗毒素在體外具有良好的活性，可競爭肉毒抗毒素馬血清與毒素的特異結合。
Human ScFv against botulinum neurotoxin serotype A(BoNTa) was modified by fusing human IgG1 Fc to C terminal of ScFv. ScFv-Fc fusion protein was expressed at high level over 30% of total host cell proteins in E. coli.
以獲得的抗A型肉毒毒素單鏈抗體為模板,進行融合改構,將人IgG1的Fc片段連接到ScFv的C端,在大腸桿菌中實現抗體融合蛋白ScFv-Fc的表達,表達量30%25以上,蛋白以包含體形式存在,經過體外變復性的抗體融合蛋白ScFv-Fc,進行Prote in G Sepharose柱親和層析純化,純度達90%25~95%25。
Bontaş
邦塔什
abstract ： To evaluate the effect of intraprostatic injection of botulinum toxin A (BoNTA) on prostate volume and refractory urinary retention in patients with benign prostatic enlargement.
評論：作者研究于良性攝護腺肥大患者接受攝護腺內注射A型肉毒桿菌素，對于攝護腺體積與排尿改善的效果。