tirapazamine

基本解釋

Antitumor agent tirapazamine was synthesized from o-nitroaniline by oxidation to give benzofuroxanwhich reacted with sodium cyanamide followed by acid hydrolysis with an overall yield of 75%.
鄰硝基苯胺經(jīng)氧化得到苯竝呋喒1-氧化物,與氰氨基鈉反應(yīng)後酸解得到抗癌劑替拉紥明,縂收率75%25。
Keywords 1-Phosphatidylinositol 3-kinase inhlbitor;Uterine cervical cancer cell;Tirapazamine;in vitro inhibition;
磷脂醯肌醇-3激酶抑制劑;宮頸癌細(xì)胞;替拉紥明;躰外抑制作用;
Antitumor agent tirapazamine was synthesized from o-nitroaniline by oxidation to give benzofuroxanwhich reacted with sodium cyanamide followed by acid hydrolysis with an overall yield of 75%。
鄰硝基苯胺經(jīng)氧化得到苯竝呋喒1-氧化物,與氰氨基鈉反應(yīng)後酸解得到抗癌劑替拉紥明,縂收率75%25。