vicissitudes

1. N-PLURAL You use vicissitudes to refer to changes, especially unpleasant ones, that happen to someone or something at different times in their life or development. 變化; 變遷[正式] [oft N 'of' n]

Whatever the vicissitudes of her past life, Jill now seems to have come through. 不琯過去經歷了什麼世事變遷，吉爾現在似乎已經度過難關了。